Proteins producing an altered immunogenic response and methods of making and using the same

   
   

The present invention relates to a novel methods and compositions for producing hyper and hypo allergenic compositions. Specifically, the present invention comprises neutralizing or reducing the ability of T-cells to recognize epitopes and thus prevent sensitization of an individual to the protein. Alternatively, T-cell epitopes are mutated to produce increased immunogenic reactions. Moreover, naturally occuring proteins are provided.

La actual invención se relaciona con los métodos y las composiciones de una novela para producir hiperactivo y las composiciones alergénicas del hypo. Específicamente, la actual invención abarca neutralizar o la reducción de la capacidad de T-ce'lulas de reconocer epitopes y de prevenir así la sensibilización de un individuo a la proteína. Alternativomente, los epitopes de la T-ce'lula son transformados producir reacciones inmunogenéticas crecientes. Por otra parte, se proporcionan las proteínas naturales.

 
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