Ketolide antibiotics

   
   

This invention relates to compounds of the formula 1: ##STR1## and to pharmaceutically acceptable salts and solvates thereof wherein X.sup.1, X.sup.2, R.sup.2, R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are as defined herein. The compounds of formula 1 are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1.

Esta invenção relaciona-se aos compostos da fórmula 1: ## do ## STR1 e aos sais e aos solvates pharmaceutically aceitáveis disso wherein X.sup.1, X.sup.2, R.sup.2, R.sup.8, R.sup.9, R.sup.10 e R.sup.11 são como definidos nisto. Os compostos da fórmula 1 são os agentes anti-bacterianos e antiprotozoal que podem ser usados tratar várias infecções e os disorders bacterianos e protozoal relacionados a tais infecções. A invenção relaciona-se também às composições pharmaceutical que contêm os compostos da fórmula 1 e aos métodos de tratar infecções bacterianas e protozoal administrando os compostos da fórmula 1.

 
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