Salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]- isothiazole-4-carboxylic acid amide and method of production

   
   

The invention relates to hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]- isothiazole-4-carboxylic acid amide having the following formula: ##STR1## The invention also relates to pharmaceutical compositions containing the hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salts of formula I. The invention further relates to methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above salts and to methods of preparing the crystal forms of the above salts.

Вымысел относит к хлоргидрату, hydrobromide, юеми-qitratu, ацетату, p-tosylate, Л-tartratu, юеми-sukqinatu, и формам 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido ] - амиду соли mesylate isothiazole-4-carboxylic кисловочному имея following формулу: ## ## STR1 Вымысел также относит к фармацевтическим составам содержа хлоргидрат, hydrobromide, юеми-qitrat, ацетат, p-tosylate, Л-tartrat, юеми-sukqinat, и соли mesylate формулы iego. Вымысел более дальнейший относит к методам обрабатывать hyperproliferative заболевания, such as раки, в mammals, специально людях путем administering вышеуказанные соли и к методам подготовлять crystal формы вышеуказанных солей.

 
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