ABCG8 vectors, host cells, and method of making

   
   

The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, ABCG8. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of ABCG8.

A invenção atual fornece os ácidos nucleic que codificam um transporter do cholesterol da família do ABC da novela, ABCG8. As seqüências nisto-divulgadas podem ser usadas para algumas de um número de finalidades, incluindo para o diagnóstico e o tratamento de disorders cholesterol-associados, including o sitosterolemia, e para a identificação das moléculas que assocíam com e/ou modulam a atividade de ABCG8.

 
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