Method of resolving amlodipine racemate

   
   

The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,N'-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.

L'invention concerne des méthodes de résoudre l'amlodipine racémique dans les compositions enantiomerically enrichies par la précipitation avec de l'acide tartrique en présence d'un dissolvant non aqueux, tel que N, N'-dimethylacetamide. Le rapport molaire d'acid:amlodipine tartrique est de préférence moins de 0.25:1.0 ou 0.75:1.0 plus grand que.

 
Web www.patentalert.com

< Organic acid salt of amlodipine

< Method for the purification of lansoprazole

> Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments

> Cardioprotective phosphonates and malonates

~ 00145