Synthetic compounds and compositions with enhanced cell binding

   
   

Compositions of the invention include composites comprising a biomaterial having compounds thereon with enhanced cell binding with respect to collagen. These composites are useful for soft and hard tissue repair or reconstruction and for in vitro uses. Suitable compounds with enhanced cell binding include synthetic peptides that mimic the conformation necessary for recognition and docking of collagen binding species (such as cell surface receptors for collagen and fibronectin) and have the amino acid residues -Ile-Ala- folded in a .beta.-bend.

As composições da invenção incluem os compostos que compreendem um biomaterial que tem compostos thereon com a pilha realçada que liga com respeito ao collagen. Estes compostos são úteis para o reparo ou o reconstruction macio e duro do tecido e para em usos de vitro. Os compostos apropriados com o emperramento realçado da pilha incluem os peptides sintéticos que imitam o conformation necessário para o recognition e o embarcadouro de espécie obrigatória do collagen (tal como os receptors da superfície da pilha para o collagen e o fibronectin) e têm os resíduos do amino-ácido - o Ile-ile-Ala- dobrado no beta.-dobra-se.

 
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