Nucleic acid molecules encoding 10-deacetylbaccatin III-O-acetyl transferase and related products

   
   

Transacylase enzymes of Taxus cuspidata and the use of such enzymes to produce Taxol.TM., related taxoids, as well as intermediates in the Taxol.TM. biosynthetic pathway are disclosed. Examples of specific enzymes described herein include taxadienol 5-O-acetyl transacylase (TAX1) and 10-deacetylbaccatin III-10-O-acetyl transferase (TAX6). Also disclosed are nucleic acid sequences encoding the T. cuspidata transacylase enzymes.

De enzymen van Transacylase van Taxus cuspidata en het gebruik van dergelijke enzymen om Taxol. TM., verwante taxoids, worden evenals tussenpersonen in de biosynthetische weg van Taxol. te produceren TM. onthuld. Hierin de beschreven voorbeelden van specifieke enzymen omvatten taxadienol 5-o-acetyl transacylase (TAX1) en 10deacetylbaccatin iii-10-o-Acetyl transferase (TAX6). Ook onthuld worden nucleic zuuropeenvolgingen coderend de enzymen van cuspidatatransacylase van T..

 
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