Methods for treating proliferative disorders, by administering reovirus to
a Ras-mediated proliferative disorder, are disclosed. The reovirus is
administered so that it ultimately directly contacts ras-mediated
proliferating cells. Proliferative disorders include but are not limited
to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian
reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g.,
strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain
Dearing or strain Abney), as well as other serotypes or strains of
reovirus can be used. Combinations of more than one type and/or strain of
reovirus can be used, as can reovirus from different species of animal.
Either solid neoplasms or hematopoietic neoplasms can be treated.
