Rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping

   
   

The invention provides methods of identifying one or more nucleic acids in a sample. The nucleic acids, for example, expressed genes in a cell, can be identified by contacting the nucleic acids with oligonucleotides having detector tags, and selector tags to form tagged oligonucleotides. Each nucleic acid can be uniquely identified by mass-spectrophotometric analysis of the detector tag.

A invenção fornece métodos de identificar um ou mais ácido nucleic em uma amostra. Os ácidos nucleic, para o exemplo, expressaram genes em uma pilha, podem ser identificados contatando os ácidos nucleic com os oligonucleotides que têm Tag do detetor, e os Tag do seletor a dar forma etiquetaram oligonucleotides. Cada ácido nucleic pode excepcionalmente ser identificado pela análise massa-mass-spectrophotometric do Tag do detetor.

 
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