Recombinant MHC molecules useful for manipulation of antigen-specific T-cells

   
   

Two-domain MHC polypeptides useful for manipulation of antigen-specific T-cells are disclosed. These polypeptides include MHC class II-based molecules that comprise covalently linked .beta.1 and .alpha.1 domains, and MHC class I-based molecules that comprise covalently linked .alpha.1 and .alpha.2 domains. These polypeptides may also include covalently linked antigenic determinants, toxic moieties, and/or detectable labels. The disclosed polypeptides can be used to target antigen-specific T-cells, and are useful, among other things, to detect and purify antigen-specific T-cells, to induce or activate T-cells, and to treat conditions mediated by antigen-specific T-cells.

os polypeptides do Dois-domínio MHC úteis para a manipulação de T-pilhas antígeno-específicas são divulgados. Estes polypeptides incluem as moléculas Ii-baseadas classe de MHC que compreendem domínios covalently ligados do beta.1 e do alpha.1, e as moléculas Eu-baseadas classe de MHC que compreendem domínios covalently ligados do alpha.1 e do alpha.2. Estes polypeptides podem também incluir determinantes antigenic covalently ligadas, moieties tóxicos, e/ou etiquetas detectáveis. Os polypeptides divulgados podem ser usados alvejar T-pilhas antígeno-específicas, e são úteis, entre outras coisas, detectar e purify T-pilhas antígeno-específicas, para induzir ou ativar T-pilhas, e para tratar as circunstâncias mediadas por T-pilhas antígeno-específicas.

 
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