The invention relates to substituted aryl and heteroaryl (R)-Chiral
Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as
inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid
transfer protein-I) and compounds, compositions and methods for treating
atherosclerosis and other coronary artery diseases. Novel high yield,
stereoselective processes for the preparation of the chiral substituted
alkanol compounds from chiral and achiral intermediates are described.
Preferred (R)-Chiral 1-Substitutedamino-(n+1)-Alkanol compounds are
substituted (R)-Chiral N,N-bis-phenyl aminoalcohols. A preferred specific
(R)-Chiral N,N-bis phenyl aminoclcohol is the compound.
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