Macrolide antiinfective agents

   
   

Compounds of the formula ##STR1## or the 10,11-anhydro forms therefor, wherein R.sub.a is H or OH; R.sub.b is H or halogen; R.sub.c is H or a protecting group; R.sub.d is methyl; unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C) or substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); R.sub.e is H or a protecting group or is mono- or disubstituted amino carbonyl; R.sub.f is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (1-10C); substituted or unsubstituted alkynyl (1-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or --OR.sub.f may be replaced by --H; one of Z and Y is H and the other is OH or protected OH, or is amino, mono- or dialkyl-amino, protected amino, or an aminoheterocycle or Z and Y together are .dbd.O, .dbd.NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.

Os compostos do ## do ## STR1 da fórmula ou do 10,11-anhydro dão forma therefor, wherein R.sub.a é H ou OH; R.sub.b é H ou halogênio; R.sub.c é H ou um grupo protegendo; R.sub.d é methyl; alkyl unsubstituted (3-10C); alkyl substituído (1-10C); alkynyl alkenyl (2-10C) ou substituído ou unsubstituted substituído ou unsubstituted (2-10C); arilo substituído ou unsubstituted (4-14C); arylalkyl substituído ou unsubstituted (5-20C); arylalkenyl substituído ou unsubstituted (5-20C); arylalkynyl substituído ou unsubstituted (5-20C); amidoarylalkyl substituído ou unsubstituted (5-20C); amidoarylalkenyl substituído ou unsubstituted (5-20C); ou amidoarylalkynyl substituído ou unsubstituted (5-20C); R.sub.e é H ou um grupo protegendo ou é amino carbonyl mono- ou disubstituted; R.sub.f é H; alkyl substituído ou unsubstituted (1-10C); alkenyl substituído ou unsubstituted (1-10C); alkynyl substituído ou unsubstituted (1-10C); arilo substituído ou unsubstituted (4-14C); arylalkyl substituído ou unsubstituted (5-20C); ou -- OR.sub.f pode ser substituído pelo --H; um de Z e Y é H e o outro é OH ou OH protegido, ou é amino, mono- ou dialkyl-amino, amino protegidos, ou um aminoheterocycle ou um Z e um Y são junto dbd.O, dbd.NOH ou um oxime derivatized; including todos os sais pharmaceutically aceitáveis disso e quaisquer formulários e misturas stereoisomeric de formulários stereoisomeric disso, são os agentes antimicrobial.

 
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