The present invention provides a method of identifying a membrane
dipeptidase (MDP)-binding homing molecule that selectively homes to lung
endothelium. The method includes the steps of contacting MDP with one or
more molecules; and determining specific binding of a molecule to the MDP,
where the presence of specific binding identifies the molecule as a
MDP-binding homing molecule that selectively homes to lung endothelium.
Such MDP-binding homing molecules can be linked to a moiety and, when
administered to a subject as a conjugate, can selectively direct the
moiety to lung endothelium in the subject.
