Phthalimido arylpiperazines useful in the treatment of benign prostatic hyperplasia

   
   

This invention relates to a series of heterocyclic substituted piperazines of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1.sub.a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.

Esta invenção relaciona-se a uma série de piperazines substituídos heterocyclic das composições pharmaceutical do ## do ## STR1 da fórmula I que contêm as e dos intermediários usados em sua manufatura. Os compostos da invenção inibem seletivamente o emperramento ao receptor adrenergic do alpha.-1.sub.a, um receptor que seja implicado na hiperplasia prostatic benigna. Porque tais os compostos são potencial úteis no tratamento desta doença.

 
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