Attenutated recombinant viruses containing DNA coding for a cytokine and/or
a tumor associated antigen, as well as methods and compositions employing
the viruses, are disclosed and claimed. The recombinant viruses can be
NYVAC or ALVAC recombinant viruses. The DNA can code for at least one of:
human tumor necrosis factor; nuclear phosphoprotein p53, wiltype or
mutant; human melanoma-associated antigen; IL-2; IFN.gamma.; IL-4; GMCSF;
IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses
and gene products therefrom are useful for cancer therapy.
Os vírus recombinant de Attenutated que contêm o coding do DNA para um cytokine e/ou um antígeno associado tumor, as.well.as os métodos e as composições que empregam os vírus, são divulgados e reivindicados. Os vírus recombinant podem ser vírus recombinant de NYVAC ou de ALVAC. O DNA pode codificar para ao menos um de: fator humano do necrosis do tumor; phosphoprotein nuclear p53, wiltype ou mutant; antígeno melanoma-associado humano; IL-2; IFN.gamma.; IL-4; GMCSF; IL-12; B7; erb-B-2 e antígeno carcinoembryonic. Os vírus e os produtos recombinant do gene são therefrom úteis para a terapia do cancer.
