This invention relates to racemic and optically active
N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguani
dine, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl-
1,2,3,4-tetrahydroquinolinyl)carboximidamide, and
N-(3-methylsulfinylphenyl)-N-methyl-N'-(2-chloro-5-methoxyphenyl)guanidine
and pharmaceutically acceptable salts thereof, and pharmaceutical
compositions and therapeutic methods of treatment that comprise such
compounds. Compounds of the invention are particularly useful for the
treatment or prophylaxis of neurological injury and neurodegenerative
disorders.
Cette invention concerne racémique et optiquement N-(2-chloro-5-methylthiophenyl)-N'-(3-methylsulfinylphenyl)-N'-methylguani actifs dinent, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl- 1,2,3,4-tetrahydroquinolinyl)carboximidamide, et N-(3-methylsulfinylphenyl)-N-methyl-N'-(2-chloro-5-methoxyphenyl)guanidine et pharmaceutiquement sels acceptables en, et compositions pharmaceutiques et méthodes de traitement thérapeutiques qui comportent de tels composés. Les composés de l'invention sont particulièrement utiles pour le traitement ou la prophylaxie des dommages neurologiques et des désordres neurodegenerative.
