Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same

   
   

This invention discloses pyrrolo pyrimidine compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, of the following formula (3): ##STR1## These compounds are useful in therapeutically and/or prophylactically treating patients with cancer by inhibiting receptor tyrosine kinases and/or dihydrofolate reductase and/or thymidylate synthase. Methods of using these compounds, are also disclosed.

Esta invención divulga compuestos del pyrimidine del pyrrolo, y farmacéutico las sales, los solvates y los prodrugs aceptables de eso, del fórmula siguiente (3): ## del ## STR1 Estos compuestos útiles adentro terapéutico y/o prophylactically están tratando a pacientes con el cáncer inhibiendo synthase de los kinases del tyrosine del receptor y/o del reductase y/o del thymidylate del dihydrofolate. Los métodos de usar estos compuestos, también se divulgan.

 
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