Folypolyglutamyl synthetase gene transfer to enhance antifolate

   
   

Methods of killing neoplastic cells are provided. The invention relates to the use of folylpolyglutamyl synthetase (FPGS) gene transfer to enhance the sensitivity of several types of tumor cells to polyglutamylatable antifolate drugs, such as methotrexate (MTX) and edatrexate (EDX).

Methoden des Tötens der neoplastischen Zellen werden zur Verfügung gestellt. Die Erfindung bezieht auf dem Gebrauch von Genübertragung der folylpolyglutamyl Synthetase (FPGS), die Empfindlichkeit einiger Arten Tumorzellen zu den polyglutamylatable antifolate Drogen, wie methotrexate (MTX) und edatrexate (EDX) zu erhöhen.

 
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