Anti-human medullasin monoclonal antibody process for producing the same and immunoassay using the same

   
   

A monoclonal antibody by which medullasin that is a kind of serine proteases existing in granulocytes, production process thereof and an immunoassay of human medullasin using the antibody are disclosed. The monoclonal antibody specifically recognizes human medullasin. The process for producing the anti-human medullasin antibody comprises culturing hybridomas prepared by cell fusion between antibody-producing cells recovered from an animal immunized with human medullasin and myeloma cells, and recovering anti-human medullasin monoclonal antibody which specifically recognizes human medullasin from the culture in which the hybridomas are cultured. The immunoassay utilizes the anti-human medullasin antibody.

Un anticorps monoclonal par lequel le medullasin qui est un genre de protéases de sérine existant dans les granulocytes, le procédé de production en et un immunoassay du medullasin humain employant l'anticorps sont révélés. L'anticorps monoclonal identifie spécifiquement le medullasin humain. Le procédé pour produire l'anticorps anti-humain de medullasin comporte cultiver des hybridomas préparés par fusion de cellules entre les cellules anticorps-productrices récupérées d'un animal immunisé avec le medullasin humain et les cellules de myélome, et récupérer l'anticorps monoclonal de medullasin anti-humain qui identifie spécifiquement le medullasin humain de la culture dans laquelle les hybridomas sont cultivés. L'immunoassay utilise l'anticorps anti-humain de medullasin.

 
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