Effervescent drug delivery system for oral administration

   
   

The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

As composições pharmaceutical da invenção atual compreendem oral os formulários de dosage administerable que usam o effervescence como um enhancer da penetração para as drogas sabidas, ou suspeitado, de ter o bioavailability pobre. O effervescence pode ocorrer no estômago, uma vez que a tabuleta ou o outro formulário de dosage ingested. Além ao effervescence no estômago, ou como a técnica alternativa, pelo uso de revestimentos apropriados e de outras técnicas, o effervescence pode ocorrer em outras partes do intervalo gastrointestinal, including, mas não limitado a, do esophagus, do duodenum, e dos dois pontos. O local do effervescence e da liberação da droga é escolhido corresponder com o segmento do intervalo gastrointestinal que indica o absorption máximo da droga formulada, ou ganhar alguma outra vantagem therapeutic.

 
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