Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors

   
   

Hydroxamic acids having the formula ##STR1## are useful in treating disease conditions mediated by TNF-.alpha., such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.

Os ácidos hydroxamic que têm o ## do ## STR1 da fórmula são úteis em condições de tratamento da doença mediadas por TNF-.alpha., tal como o arthritis rheumatoid, a osteodistrofia, o sepsis, o AIDS, o colitis ulcerative, o sclerosis múltiplo, a doença de Crohn e a perda degenerative do cartilage.

 
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