Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals

   
   

The invention is directed to oligonucleotides and oligonucleosides functionalized to include lipophilic moieties and having improved biostability and altered biodistribution in mammals. In one embodiment, such lipophilic oligonucleotide conjugates are used in a method of targeting antisense oligonucleotides to hepatic tissues and thereby preferentially modulating gene expression in the liver and associated tissues of a mammal.

La invención se dirige a los oligonucleotides y los oligonucleosides functionalized para incluir moieties lipofílicos y mejorando biostability y alteraron el biodistribution en mamíferos. En una encarnación, tales conjugaciones lipofílicas del oligonucleotide se utilizan en un método de apuntar los oligonucleotides del antisense a los tejidos finos hepáticos y de tal modo preferencial de modular la expresión del gene en el hígado y los tejidos finos asociados de un mamífero.

 
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