Compounds and therapies for the prevention of vascular and non-vascular pathologies

   
   

The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compounds that elevate TGF-beta levels, as well as pharmaceutical compositions comprising compounds that elevate TGF-beta levels, and methods for detecting diseases associated with endothelial cell activation.

La invención proporciona un método de tratar tener mammal, o en el riesgo de, una indicación asociada a una deficiencia TGF-beta que abarca administrando unos o más agentes que sea eficaz elevar el nivel de TGF-beta. La invención también proporciona los compuestos de la novela que elevan niveles TGF-beta, tan bien como las composiciones farmacéuticas que abarcan los compuestos que elevan niveles TGF-beta, y los métodos para detectar las enfermedades asociadas a la activación endothelial de la célula.

 
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