Antibodies against a secreted polypeptide that stimulates release of proteoglycans from cartilage

   
   

The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

La présente invention est dirigée vers les polypeptides sécrétée et de transmembrane et vers des molécules d'acide nucléique codant ces polypeptides. En outre fournis ci-dessus sont des vecteurs et les cellules hôtes comportant ces ordres d'acide nucléique, molécules chimériques de polypeptide comportant les polypeptides de la présente invention fondue aux ordres hétérologues de polypeptide, les anticorps qui lient aux polypeptides de la présente invention et aux méthodes pour produire les polypeptides de la présente invention.

 
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