Virus-like particles for the induction of autoantibodies

   
   

The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or conjugated virus-like particles, and methods of use of the foregoing are provided for the study of B cell tolerance and the treatment or prevention of human diseases, which involve the onset of B cell tolerance, such as chronic viral infection, chronic inflammatory disease, and neoplasia.

A invenção descrita nisto relaciona-se às composições e aos métodos para estimular respostas imunes em vivo de encontro a um tolerogen. As ferramentas, os pharmaceuticals, o therapeutics e o prophylactics, que concernem chimeric ou conjugated vírus-como partículas, e os métodos biotechnological da novela do uso do antecedente são fornecidos para o estudo da tolerância da pilha de B e do tratamento ou a prevenção das doenças humanas, que envolvem o início da tolerância da pilha de B, tal como a infecção viral crônica, da doença inflammatory crônica, e do neoplasia.

 
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