Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen

   
   

A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the CB10 peptide of mammalian type II collagen, or an antibody-binding fragment or variant thereof, for a time and under conditions for an antibody-antigen complex to form, and detecting the antibody-antigen complex, for example by immunoassay. A diagnostic test kit is also disclosed.

Una prueba profética para la artritis reumatoide abarca la detección de anticuerpos al colágeno en una muestra biológica de un paciente entrando en contacto con la muestra biológica con un antígeno que abarca el peptide CB10 del tipo mamífero colágeno de II, o un fragmento o una variante anticuerpo-que ata de eso, por una época y bajo condiciones para un complejo del anticuerpo-anti'geno a la forma, y detectando el complejo del anticuerpo-anti'geno, por ejemplo por immunoassay. Un kit de la prueba de diagnóstico también se divulga.

 
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