This invention provides isolated nucleic acids encoding mammalian NPFF
receptors, purified mammalian NPFF receptors, vectors comprising nucleic
acid encoding mammalian NPFF receptors, cells comprising such vectors,
antibodies directed to mammalian NPFF receptors, nucleic acid probes
useful for detecting nucleic acid encoding mammalian NPFF receptors,
antisense oligonucleotides complementary to unique sequences of nucleic
acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which
express DNA encoding normal or mutant mammalian NPFF receptors, methods of
isolating mammalian NPFF receptors, methods of treating an abnormality
that is linked to the activity of the mammalian NPFF receptors, as well as
methods of determining binding of compounds to mammalian NPFF receptors,
methods of identifying agonists and antagonists of NPFF receptors, and
agonists and antagonists so identified.
Esta invenção fornece os ácidos nucleic isolados que codificam os receptors mammalian de NPFF, receptors mammalian purified de NPFF, vetores que compreendem o ácido nucleic que codifica os receptors mammalian de NPFF, pilhas que compreendem tais vetores, antibodies dirigidos aos receptors mammalian de NPFF, pontas de prova do ácido nucleic úteis para detectar o ácido nucleic codificar os receptors mammalian de NPFF, oligonucleotides do antisense complementares às seqüências originais do ácido nucleic que codificam os receptors mammalian de NPFF, os animais transgenic, nonhuman que o normal codificando expresso do DNA ou os receptors mammalian do mutant NPFF, métodos de isolar os receptors mammalian de NPFF, métodos de tratar um abnormality que seja ligado à atividade dos receptors mammalian de NPFF, as.well.as métodos de determinar ligar dos compostos aos receptors mammalian de NPFF, os métodos de identificar agonists e antagonistas dos receptors de NPFF, e os agonists e os antagonistas identificados assim.
