Inhibition of TNF.alpha.-initiated neutrophil response
   
   

The impact of lipoxin A.sub.4 (LXA.sub.4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF.alpha.)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1-10 nM, the LXA.sub.4 and ATL analogs each inhibited TNF.alpha.-stimulated superoxide anion generation and IL-1.beta. release by human PMN.

O impacto do lipoxin A.sub.4 (LXA.sub.4) e aspirina-provocou-lipoxins (ATL) foi investigado no fator do necrosis do tumor (respostas do neutrophil de TNF.alpha.)-initiated (PMN) em vitro e em vivo usando metabolically analogs estáveis de LX. Nas concentrações tão baixas quanto nM 1-10, os LXA.sub.4 e os analogs de ATL cada geração do anion do superoxide de TNF.alpha.-stimulated e IL-1.beta. inibidos liberam-se por PMN humano.
 
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