Methods are disclosed for refolding proteins of the TGF-.beta. family of proteins. The methods employ as refolding agents one or more compounds which are non-detergent zwitterionic compounds, such as sulfobetaines, substituted pyridines, substituted pyrroles and acid substituted aminocyclohexanes.

Методы показаны для refolding протеинов семьи TGF-.beta. протеинов. Методы используют как refolding вещества one or more смеси будут non-detergent zwitterionic смесями, such as sulfobetaines, замененными пиридинами, замененными пирролами и замененными кислотой aminocyclohexanes.