The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other genetic mutation. Clonally expanded macrophages induce proliferation of surrounding tissue leading to cancerous tumor growth. The invention provides methods and kits for diagnosis of HIV- and non-HIV-associated clonal expansion of macrophages in pre-cancerous and cancerous tissue. The invention also provides methods for the treatment of cancers induced by clonal macrophage expansion and proliferation of surrounding tissue.

A presença de macrophages clonal no tecido pre-cancerous e cancerous representa um estágio adiantado da doença em que a expansão clonal dos macrophages ocorre devido à integração do HIV ou ao outro mutation genetic. Os macrophages expandidos Clonally induzem o proliferation de tecido circunvizinho que conduz ao crescimento cancerous do tumor. A invenção fornece métodos e jogos para o diagnóstico do HIV- e expansão clonal non-HIV-associada dos macrophages no tecido pre-cancerous e cancerous. A invenção fornece também métodos para o tratamento dos cancers induzidos pela expansão do macrophage e pelo proliferation clonal de tecido circunvizinho.