The present invention provides a drug-eluting stent, wherein the stent is coated with one or more non-nucleotide P2Y.sub.12 receptor antagonist compounds or a pharmaceutically acceptable salt, solvate, or hydrate thereof. When the stent is placed in a narrowed or damaged arterial vessel, a therapeutically effective amount of the P2Y.sub.12 receptor antagonist compound is eluted continuously from the stent to the local environment of the stent. The P2Y.sub.12 receptor antagonist compound-eluting stents are useful in preventing thrombosis and restenosis, and are effective in inhibiting the contraction of vascular smooth muscle cells, inhibiting cell proliferation, and reducing inflammation.

 
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