The present invention concerns modified oligonucleotides and processes for their production wherein these oligonucleotides contain at least once the structure P.dbd.N-Acc where Acc is an electron acceptor or an electron acceptor substituted with a residue R and R is any organic substituent.

 
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> Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
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