This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.

 
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> Polypeptide variants

> Prodrugs of 5-amino-3-(3'-deoxy-.beta.-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-- dione

~ 00617