A detachable saddle and a pad-replaceable saddle set are provided. The detachable saddle comprises a base, a pad and a fastening device, wherein the base has a top surface, the pad has a bottom surface, and the fastening device, disposed between the top surface of the base and the bottom surface of the pad, is adapted to detachably assemble and substantially form a cushion space between the base and the pad. The pad-replaceable saddle set comprises said base, said fastening device and a plurality of pads, wherein each pad is assembled with the base to form a complete detachable saddle. Thereby, cyclists may conveniently and readily detach and replace the pads of the pad-replaceable saddle set.