An apparatus (500) for detecting removal of items from a compartment is disclosed. The apparatus comprises a reader (540) for reading Radio Frequency Identification (RFID) tags attached to items in the compartment and a processor (510), coupled to the reader (540), for identifying items removed from the compartment. Removal of an item from the compartment is detected based on absence of a RFID tag that was previously detected by the reader (540). The RFID tags may be read exclusively when a door of the compartment is closed and the apparatus may further comprise a detector coupled to the processor (510) for detecting open/close status of the door. Removal of an item is preferably confirmed only when a RFID tag attached to an item has been absent from the compartment for longer than a defined time period.