A compound of formula (I) ##STR00001## wherein R.sup.1 and R.sup.3 are
the same or different and represent .dbd.O, hydrogen, C.sub.1-6alkyl,
C.sub.1-6dialkyl, .dbd.CHC.sub.1-C.sub.5alkyl, .dbd.S, or a 5- or
6-membered aryl; R.sup.4 to R.sup.9 are the same or different and
represent hydrogen, C.sub.1-6alkoxy, OCF.sub.3, OCH.sub.2CF.sub.3,
O-cyclopropyl, OCH.sub.2-cyclopropyl, C.sub.1-C.sub.6alkyl, S-alkyl,
NR.sub.2.sup.10 where R.sup.10 is hydrogen or C.sub.1-6alkyl, halogen,
NO.sub.2, OH, CH.sub.2OC.sub.1-C.sub.6alkyl, CH.sub.2OH, or CF.sub.3;
Q.sup.1 is hydrogen, C.sub.1-6alkyl, C.sub.1-6dialkyl, C.sub.1-6alkoxy,
NHAc, NR.sub.2.sup.10 where R.sup.10 is hydrogen or C.sub.1-6alkyl,
difluoro, fluoro, .dbd.O, or OH; Q.sup.2, Q.sup.3, Q.sup.4 and Q.sup.5
are the same or different and represent hydrogen, C.sub.1-6alkoxy,
OCF.sub.3, OCH.sub.2CF.sub.3, O-cyclopropyl, OCH.sub.2-cyclopropyl,
C.sub.1-C.sub.6alkyl, S-alkyl, NR.sub.2.sup.10 where R.sup.10 is hydrogen
or C.sub.1-6alkyl, halogen, NO.sub.2, OH, CH.sub.2OC.sub.1-C.sub.6alkyl,
CH.sub.2OH, or a 5- or 6-membered aryl; with the proviso that the
compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propio-
nic acid, sodium salt and
[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic
acid are excluded; and pharmaceutically acceptable derivatives thereof.
