A communication system optimizes cell edge performance and spectral efficiency by determining an adaptive power control parameter based on system performance metrics measured by a serving Node B and further measured by, and reported to the serving Node B by, neighboring Node B's. The adaptive power control parameter is then used to determine an uplink transmit power of a user equipment (UE) served by the serving Node B. The uplink transmit power may be determined by the Node B and then conveyed to the UE, or the Node B may broadcast the adaptive power control parameter to the UE and the UE may self-determine the uplink transmit power. In addition, as a frequency reuse factor of one has been proposed for such communication systems, interference levels may be even further improved by employment of an intra-site interference cancellation scheme in the sectors serviced by the Node B.