Cellular targets for anti-retroviral drug development are disclosed. The
cellular targets comprise ATR kinase and its relevant substrates, based
on the identification of the ATR kinase as required for the final step of
retroviral DNA integration. Assays for identifying modulators of
retroviral integration via the ATR kinase pathway are disclosed, as well
as modulators identified by such assays. Pharmaceutical preparations and
methods of their use in treating retroviral infection are also disclosed.
