Methods and systems for facilitating communications and commerce between remote device users and merchants or sponsors, particularly adapted for small-screen portable devices such as cellular telephones and personal digital assistants. The invention enables sponsors to quickly and easily, without the requirement for specialized or expensive equipment, establish Web sites to advertise their products and services. The invention provides unique, intuitive graphical interfaces enabling users to find Web sites of interest easily and quickly amongst many sites. In addition to real-time, direct sponsor-user communications, the system further includes features such as response time prioritization, which enable users to quickly determine the relevance of a sponsor response.