A manufacturing method and apparatus produces various medium such as mineral substance, vitamin substance, or ceramic that include negative hydrogen icons for use by human beings and animals. In the manufacturing method, an optional mineral substance or vitamin substance as the medium in granular or powdered form is supplied to the inside of the container and filled with liquid hydrogen or hydrogen, gas. Then after leaving them in the container for a predetermined time, the medium is removed to be air dried, thereby producing the medium which is combined and included with negative hydrogen ion. Alternatively, high pressure, heat, or high voltage may be applied to the medium to contain the negative hydrogen ion in the medium.