The present invention provides a pharmaceutical composition for preventing and/or treating periodontal disease comprising at least one having dental root-periodontal tissue formation promotion effect selected from the group consisting of a compound shown in a following formula (I). ##STR00001## (In the formula, R.sub.1 and R.sub.2 are independently functional groups selected from a group consisting of a substituted or non-substituted group of a linear alkyl group, a branched alkyl group, a linear alkenyl group and a branched alkenyl group with having the carbon number of 3 to 5. R'.sub.1 and R'.sub.2 are independently a hydrogen atom, hydroxyl group, or alkoxy group having the carbon number of 1 to 3.)