The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Le.sup.a structure, a Le.sup.a-lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.

 
Web www.patentalert.com

< COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF FACTOR VII GENES

< Pharmaceutical product

> NOVEL SHIGELLA PROTEIN ANTIGENS AND METHODS

> PATHOGEN-INDUCIBLE PROMOTERS AND THEIR USE IN ENHANCING THE DISEASE RESISTANCE OF PLANTS

~ 00608