The invention relates to a wrist orthosis with a cuff, which is open for passage of the thumb and which is provided with stabilizing rods and with at least one tightening strap for fixing the orthosis on the wrist. The cuff has two adjacent thumb openings for receiving either the left or right thumb, wherein a central stabilizing rod extends between the thumb openings, and a lateral stabilizing rod extends along the outer side of each said opening in such a manner that the thumb openings are each located between the central stabilizing rod and the relevant lateral stabilizing rod.