Methods and systems for navigating medical devices are provided. A patient is imaged while a medical device is moved within the patient. A position (e.g., a location and/or orientation) of the moving medical device is detected within a coordinate system (e.g., a three-dimensional coordinate system), a position of the imaging field of view relative to the patient is adjusted based on the detected medical device position, such that the relevant tissue region of the patient is within the field of view. For example, the field of view can be centered over the medical device or centered just distal to the medical device portion. The direction of view may be oriented at an angle perpendicular to the axis of the medical device, e.g., for more accurately measuring the length of objects within the field of view, or oriented at an angle parallel to the axis of the medical device portion, e.g., for more accurately measuring the diameter of the channel (e.g., blood vessel) in which the medical device is disposed.