The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I ##STR00001## The present invention also provides methods for the use thereof to inhibit .beta.-secretase (BACE) and treat .beta.-amyloid deposits and neurofibrillary tangles.

 
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> Amyloid specific binding peptides and detecting abeta peptide

> (4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease
~ 00601