A chimeric polypeptide comprising a TNF neutralizer domain, an IL-1
receptor antagonist domain, and a dimerization domain, wherein the three
domains are operably linked to each other. Within the scope of this
invention are (i) nucleic acids encoding the polypeptide; (ii) expression
vectors and host cells containing the nucleic acids; (iii) related
pharmaceutical compositions; and (iii) related preparation and treatment
methods.