An X-ray generation unit and an X-ray detection unit are controlled by an imaging control unit when two-dimensional images of a sample without a contrast and two-dimensional images of a sample with a contrast are imaged, so as to set imaging angles of these two-dimensional images to be different from each other, and a three-dimensional image of the sample is acquired by an image calculation unit on the basis a plurality of two-dimensional images without a contrast and a plurality of two-dimensional images with a contrast which are acquired under the control of the X-ray generation unit and the X-ray detection unit.