Compounds of the substituted 1,3-dialkyl-2,4-dioxo-6-(arylamino)-1,2,3,4-tetrahydropyrimidine-5-hydrox- amic acids, show below: ##STR00001## wherein the variables are as defined herein, and pharmaceutical compositions thereof, are provided for use as inhibitors of with MEK kinase.

 
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> Pyrrolidin-2-one derivatives for use as DP.sub.1 receptor agonists

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