A wireless communication system and handover method for the wireless communication system are provided. A handover method for a wireless communication system including a plurality of femto cells and at least one macro cell within which the femto cells are disposed includes determining, at a Radio Network Controller (RNC), a handover of a terminal to a femto base station based on a measurement report of the terminal and preset handover parameters, sending a radio link setup request message to a femto base station gateway, the radio link setup request message including a uplink scrambling code and an International Mobile Subscriber Identity (IMSI) of the terminal and a Logical Cell Identifier (LCID) of femto base stations reusing frequency of a macro base station, searching, at the femto base station gateway, for femto base stations of which LCIDs match the LCID contained in the radio link setup request message, and performing, when only one LCID-matched femto base station is discovered, the handover of the terminal to the LCID-matched femto base station.