Provision of a compound having a superior androgen receptor regulating
action.
A compound represented by the formula (I)
##STR00001##
wherein R.sup.1 is a hydrogen atom, a halogen atom, a group via a carbon
atom, a group via a nitrogen atom, a group via an oxygen atom or a group
via a sulfur atom; R.sup.2 is a hydrogen atom, a halogen atom, a group
via a carbon atom, a group via a nitrogen atom, a group via an oxygen
atom or a group via a sulfur atom; R.sup.3 is an electron-withdrawing
group; R.sup.4 is a hydrogen atom, a halogen atom, a group via a carbon
atom, a group via a nitrogen atom, a group via an oxygen atom or a group
via a sulfur atom; R.sup.5 is a hydrogen atom, a halogen atom, a group
via a carbon atom, a group via a nitrogen atom, a group via an oxygen
atom or a group via a sulfur atom; R.sup.6 is a hydrogen atom, a halogen
atom, a group via a carbon atom, a group via a nitrogen atom, a group via
an oxygen atom or a group via a sulfur atom; R.sup.7 is alkyl optionally
having substituent(s); R.sup.8 is a hydrogen atom, alkyl optionally
having substituent(s), alkenyl optionally having substituent(s) or
cycloalkyl optionally having substituent(s); R.sup.9 is a group via an
oxygen atom; and ring A is a 5- or 6-membered ring optionally having
substituent(s) other than R.sup.6 to R.sup.9 (excluding
2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-methylbenzonitri-
le, 2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile,
4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile,
2-chloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-5-methylbenzonitri-
le, 2-chloro-3-ethyl-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonit-
rile, 4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-2-(trifluoromethyl)ben-
zonitrile, 2,3-dichloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-5-me-
thylbenzonitrile,
2,3-dichloro-4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]benzonitrile,
4-[(2S,3S)-3-hydroxy-2-methylpyrrolidin-1-yl]-3-(trifluoromethyl)benzonit-
rile, 4-[(2S,3S)-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)-
benzonitrile,
4-[(2S,3R)-3-hydroxy-2-isopropylpyrrolidin-1-yl]-2-(trifluoromethyl)benzo-
nitrile, and
2-chloro-4-[(2S)-3-hydroxy-2-methylpiperidin-1-yl]benzonitrile), or a
salt thereof.
